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KMID : 0383820070620020105
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Tuberculosis and Respiratory Diseases
2007 Volume.62 No. 2 p.105 ~ p.112
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The Efficacy of α-Lipoic Acid on the Endotoxin-induced Acute Lung Injury
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Hur Jin-Won
Koh Youn-Suck
Lim Chae-Man
Hong Sang-Bum
Kim Mi-Jung
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Abstract
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Background:Oxidative stress may play an important role in the pathogenesis of endotoxin-induced acute lung injury (ALI). This study evaluated the therapeutic effect of alpha-lipoic acid, a nonenzymatic antioxidant, in a rat model of lipopolysaccharide (LPS) induced ALI.
Materials and methods: ALI was induced in Sprague-Dawley rats by instilling LPS (E.coli, 3mg/Kg) into the trachea. The rats were classified into the control, control+alpha-lipoic acid, LPS, and LPS+alpha-lipoic acid groups.The lung lavage neutrophil count, cytokine-induced neutrophil chemoattractant (CINC), lung myeloperoxidase (MPO), and cytokine concentrations (TNF-alpha, IL-1beta, IL-6 and IL-10) were measured at 2 h and 6 h after LPS administration.
Results:The total cell and neutrophil counts of the LPS+alpha-lipoic acid groups were significantly lower than the LPS groups. The protein concentration in the BAL fluid was similar in the LPS groups and LPS+alpha-lipoic acid groups. The TNF-alpha, IL-1beta, and IL-6 concentrations in the BAL fluid were not decreased by the alpha-lipoic acid treatment in the LPS treated rats.
Conclusions:Although alpha-lipoic acid decreased the level of LPS-induced neutrophil infiltration into the lung, it could not attenuate the LPS-induced ALI at the dose administered in this study.
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KEYWORD
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α-Lipoic acid, oxidative stress, acute Lung injury, antioxidant
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